A Different Role of Metallothionein-3 (Mt3) in Oxidative Stress and Neurodegeneration of Brain
نویسنده
چکیده
Brain injury comes from various pathological conditions. Among those, acute brain injuries such as trauma and ischemia are mainly caused in the oxidative stress of brain cells [1-3]. Labile zinc accumulation in the brain significantly contributes to oxidative brain injury [4-8]. On the other hand, neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Parkinson’s (PD), Alzheimer’s (AD), and Huntington’s (HD) are caused by progressive loss of structure or function of neurons. Different neurodegenerative disorders show many parallels including atypical protein assemblies as well as induced cell death [9,10]. Unlike the case of oxidative injury, zinc deficiency in the brain aggravates chronic neurodegeneration [11], suggesting that zinc dyshomeostasis plays a key role in the brain diseases.
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